Performance and Durability of Cryopreserved Allograft Aortic Valve Replacements

BackgroundThe value of allografts for aortic root replacement is controversial, with recent concern about limited durability. Currently, we prefer invasive infective endocarditis. Purposes this study were to assess allograft performance and durability in our cumulative experience allografts.MethodsFrom January 1987 2017, 2042 adults received 2110 replacements at institution: 986 (47%) endocarditis (669 [68%] prosthetic valve endocarditis) 1124 (53%) other indications. Mean recipient age was 54 ± 15 years, mean donor 35 13 years. Follow-up 85% complete comprised 17,253 patient-years data. Longitudinal extracted from 6339 available echocardiographic studies. Durability assessed by explant structural failure.ResultsAllograft gradient hospital discharge 6 mm Hg 9, 13, 5, 10, years post-implant, respectively. Severe regurgitation 0% discharge, but 14%, 25%, 35% A total 405 explanted failure, actuarially 2%, 34%, 51% 15, 20 Risk factors failure younger age, larger body surface area, hypertension, thoracic aorta disease; older size. Implant not associated accelerated failure.ConclusionsThis affirms allografts’ long-term acceptable hemodynamic Concern should limit use. Recipient size, are modifiable risk factors. The allografts. From failure. Allograft This